Kidney Disease: A Strong Indicator of the Risk of Death and ESRD

Two new studies from the Johns Hopkins Bloomberg School found that kidney disease is linked with risk of death andESRD even in patients without high blood pressure and Diabetes. Both hypertension and Diabetes are common conditions with Chronic Kidney Disease (CKD) with hypertension being the most prevalent.

Approximately 10% to 16% of all adults in Asia, Europe, Australia and USA have been affected by CKD. In the hypertension meta-analysis, low renal function and high urine protein was associated with all-cause and cardiovascular mortality and ESRD in both persons with and without hypertension.

The association of kidney function and proteinuria with mortality outcomes were stronger in persons without hypertension than in those with hypertension, whereas the renal function and proteinuria associations with ESRD didn't differ by hypertensive status.

In the analysis of Diabetes, people with diabetes had a higher risk of all-cause cardiovascular mortality and ESRD compared to those who have no Diabetes.

According to one of the lead authors, CKD should be considered as at least an equally relevant risk factor for mortality and ESRD in people who have no high blood pressure as it is in those with hypertension.

"The conclusions are also strengthened by the findings of leading studies and the participation of investigators from 40 countries and a detailed analysis of more than 1 million participants," said a professor in the Bloomberg School's Department of Epidemiology.

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