• IgA Nephropathy

    IgA nephropathy - m.kidneyabc, IgA Nephropathy Hospital

IgA Nephropathy Treatment

iga nephropathy treatment

IgA Nephropathy (Berger's disease) is a relatively common kidney disease that affects millions of people worldwide. IgA is a protein produced by the immune system of the body to help fight infection. In IgA Nephropathy, this antibody deposits in the mesangium of glomeruli and causes inflammation and scarring in the kidney.

Treatment should focus on removing IgA immune complexes, blocking further decline of kidney function, as well as recovering the overall kidney function maximally.

1. Symptomatic treatment

Control blood pressure and limit the amount of protein in the urine. Medicines including ACE inhibitors and ARBs can help us achieve both of these purposes.

Corticosteroids, other immunosuppressive drugs, and fish oil have also been used to treat this disorder.

Limit the intake of salt and fluids to control swelling. In some cases, a low to moderate protein diet may be recommended.

People who have progress to end-stage renal failure have to adopt one renal replacement therapy to sustain life: Dialysis or Kidney Transplant.

Though the symptoms of IgA Nephropathy can be alleviated with the above symptomatic treatments, the disease often relapses easily.

2. Holistic treatment-Immunotherapy

Nowadays, immunology has become the most popular research all over the world. Recent study shows that IgA Nephropathy is an auto immune disease causing by immune dysfunction. In this case, immune complex can be produced and deposit in the kidneys, launching a series of pathological changes.

Based on many years' clinical practices, Immunotherapy comes into being as the newest treatment for IgA Nephropathy in China. The whole process can be divided into six steps:

1. An accurate diagnosis. A comprehensive diagnosis and evaluation of each patient's present illness condition is necessary to guide the best treatment plan.

2. Immune blocking. The immune inflammatory response will be restrained rapidly with a set of immune blocking therapeutic methods.

3. Immune clearance. By means of immunosorption, plasmapheresis and blood purification, etc, the harmful substances in the blood can be eliminated completely.

4. Immune tolerance. Though inflammatory damages of tissue and cells caused by immune response have been prevented by immune blocking, the damaged renal inherent cells and immune complexes haven't been removed. It is necessary to help patients adapt this fact. Meantime, regular immune blocking should be adopted.

5. Immune adjustment. On the one hand, immune complex can be cleared away by Traditional Chinese Medicine. On the other hand, we put stress on improving the immunity of the whole body.

6. Immune protection. The integrated of Chinese and western medicine are used to protect and repair the damaged renal tissue and inherent cells. Meanwhile, the immune system will get regulated gradually.

Immunotherapy can treat IgA Nephropathy from the root cause and prevent the relapse. Patients should keep in mind that systemic and consistent treatments are essential to your recovery.

If you have been diagnosed with IgA Nephropathy, we're here to help. Call us: +86-135-03211882 or email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

IgA Nephropathy Symptoms

Symptoms for IgA Nephropathy do not occur at the beginning stages of the disease. The disease is a progressive condition, so it can take decades before patients present any symptoms. In some cases, the doctor may detect signs of this disorder during a routine screening. Signs and symptoms of IgA Nephropathy include:

iga nephropathy symptoms

·Cola- or tea-colored urine caused by blood in the urine, or hematuria

·Pain in the sides, flanks, abdomen, or loins

·Foamy or bubbly urine due to protein in the urine, or proteinuria

·High blood pressure

·Low-grade fever

·Fatigue

·Swelling (edema) of the hands and feet

·Flu and cold-like symptoms

·Mood swings

·Becoming more susceptible to allergies

·Lack of response to cold temperatures (mainly in children)

·Urinary tract infections (mainly in young girls)

It is common for people to have IgA Nephropathy for years without developing signs or symptoms and without knowing they have the disease. If you have some of the above signs and symptoms, see your doctor to discuss what might be causing them.

If you have been diagnosed with IgA Nephropathy, we're here to help. Call us: +86-135-03211882 or email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

  • IgA Nephropathy Symptoms Related Articles

IgA Nephropathy Basic

iga nephropathy basics

What is IgA Nephropathy?

The primary type of IgA Nephropathy (or IgAN, Berger's disease) is an immune-complex-medicated glomerulonephritis defined by the presence of IgA deposits in the mesangial area of the kidney.

Immunoglobulin A (IgA) plays a role in mucosal immunity and is produced in mucosal linings. Hence, it can be found in mucous secretions such as tears, saliva, secretions from the gastrointestinal tract, etc. It is found only in small amounts in blood.

The onset of IgAN can be associated with the upper respiratory tract infection, and the disease may occur due to the hyperactivity of the mucosal immune system.

When you get an infection, antigens (a virus, bacteria, or toxin) can easily invade into your body, the body sends out antibodies, which are immunoglobulins produced by the immune system, to fight against these invaders.

However, antibodies fail to fight off these antigens, but lock onto the surfaces of foreign substances, forming antigen-antibody aggregates known as immune complexes. Normally, these objects will circulate through the blood stream until being removed by the liver and other organs. In IgAN, however, they become deposited, or lodged in the tiny filters of the kidney-glomeruli.

These deposits don't belong to our body, so the body will try to eliminate them. The immune complexes are too stubborn to be cleared away, so the inflammatory response will become more and more tense, eventually resulting in hypersensitivity. The renal intrinsic cells and tissues will be impaired if the hypersensitivity is out of control. Symptoms will occur over time.

Causes of IgA Nephropathy

1. Infection and Inflammatory reaction

The attack of IgAN is often followed by an infection, especially infection of the upper respiratory tract. Infection will cause inflammatory reaction inside the body which affects mesangial cells, resulting in secretion of inflammatory cytokines. Finally, massive immune complexes accumulate in the mesangial area of kidney.

2. Genetic predisposition

Researches showed that a part of IgAN patients exhibit familial aggregation of the disease, which indicated that IgAN may inherit.

3. IgA deposition in the mesangial area

Deposition of IgA and other immune complexes in the mesangial area destroy the normal structure of certain renal intrinsic cells, thus causing kidney damage.

If you have been diagnosed with IgA Nephropathy, we're here to help. Call us: +86-135-03211882 or email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

IgA Nephropathy Healthy Living

iga nephropathy health care

While receiving effective treatment of IgA Nephropathy, patients should pay attention to the daily care, because a healthy lifestyle can also prevent IgA Nephropathy from developing into Uremia. The following are some useful suggestions for your reference.

·Prevention of inflammatory diseases.

Try to prevent inflammatory diseases such as upper respiratory tract infection, urinary tract infection, skin infection, intestinal tract infection and fungus infection. Once there is infection, you should take measures to stop it as soon as possible.

·Balance between work and rest

Avoid over-strain and strenuous exercise, both of which are factors that may result in aggravation of the disease. It is necessary to have enough rest and proper physical activities in the daily life.

·Eat a proper diet.

People should arrange daily diets according to the specific symptoms. In general, the diet should be low in sodium, protein, fat, potassium and phosphorus.

·Self-monitor

Pay attention to control the blood pressure, observe the change of urine volume, and avoid inducements of hematuria.

·Keep a positive attitude toward life.

A good mood is important to your recovery. Don't be too worried and afraid. You should have confidence to overcome the disease.

If you have been diagnosed with IgA Nephropathy, we're here to help. Call us: +86-135-03211882 or email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.