95% of kidney diseases are caused by autoimmune disease. The tests are performed to help diagnose autoimmune disorder for specific autoantibodies are usually present with particular abnormal immune conditions. What are autoantibodies tests?
- ANA (Antinuclear Antibody). ANA is positive SLE (Systemic Lupus Erythematosus).
- Anti-dsDNA (anti-double stranded DNA) test. Anti-dsDNA is an important index to diagnose autoimmune disease and up to 80 of those with SLE or lupus nephritis will have a positive result.
- Anti-Smith. It is very specific for SLE and positive up to 30% of those with SLE.
- Anti-SS-A. It is positive in up to 75% of those with Sjögren's syndrome; may also be positive in up to 30~50% of thoese with SLE and scleroderma.
- Anti-SS-B. Positive in up to 60% of those with Sjögren's syndrome; may also be positive up to 10~20% with those of SLE;
- Anti-RNP. IT is positive in 95-100% of MCTD; may also be positive up to 30~50% of those with SLE and Scleroderma.
- Anti-Jo-1. It may be positive with Polymyositis and Pulmonary Fibrosis
- Scl-70. It may be positive in up to 60% of those with Scleroderma.
- Anti-Glomerular Basement Membrane (GBM). It is specific to diagnose various anti-GMB Glomerulonephritis, including pulmonary-renal syndrome.
- Anti-MPO. It is the main target antigen of p-ANCA, which is positive with necoritic or crescentic Glomerulonephritis.
- Protease 3. It is the main target antigen of c-ANCA, which is specific in diagnosing Wegener's granulomatosis.
- Anti-Ro-52. It is positive with myositis, scleroderma, rheumatic disease.
- Anti-M2 Antibody. It is particular in diagnosis of primary biliary cirrhosis.
- Anti-PM-ScI Antibody. It represents a specific marker for a subset of patients with scleroderma and polymyositis.
- Anti-ACA. It is associated with Progressive Focal Sclerosis.
- Anti-PCNA Antibody. It a specific index to diagnose with SLE.
- Anti-histone Antibody. It is positive with SLE and RA.
- Anti-Rib-P Antibody. It indicates SLE and relates to lupus encephalopathy.
Why choose autoantibody tests?
Autoantibody tests may be ordered to find the autoimmune disorder, which usually is the root cause of kidney diseases. Finding the root cause helps your doctor to evaluate the serverity of your condition, monitor activity of immune disease and kidney damages, as well as assess the effectiveness of treatments.
In summary, autoantibody tests helps to figure out:
● whether your kidney damages are caused by autoimmune disorder
● how serious your autoimmune disease is
● specific drugs and cleaning method to deal with the excessive antibodies in your body.